Book chapter: Pharmacogenomics in Clinical Care and Drug Discovery
Author(s): E.Mendrinou, T.Katsila, F.Innocenti, A.Squassina, G.P.Patrinos
Published: November 4, 2017
Journal: Molecular Diagnostics (Third Edition)
Pharmacogenomics is redefining disease management and patient stratification. As such, pharmacogenomic testing has become fundamental to the development and clinical use of several molecular diagnostics as well as targeted therapies. There are still barriers (scientific, economic, educational, ethical, legal) that need to be overcome prior to the application of pharmacogenetic/pharmacogenomic technologies toward innovative clinical strategies and optimized therapeutic outcomes. For this to be achieved, continued research and the participation of all involved stakeholders is critical. This chapter aims to summarize the current knowledge on how the discipline of genetics and genomics can influence drug discovery and development and more broadly the practice of health care.