Centro Nacional de Investigaciones Oncológicas
Area of work: Bioinformatics
Role: Full Partner
Address: Calle de Melchor Fernández Almagro, 3, Madrid, 28029, Spain
Role in RD-Connect:
The group will participate in the Bioinformatics work packages, including the construction of the federated database, the integration of the analysis pipeline, the organisation of the annotation jamborees /data releases, and the development of the analysis instruments and workflows.
The CNIO Structural Biology and Biocomputing Programme has contributed to the creation of bioinformatics methods in areas of genome annotation, information extraction and network analysis. These methods are in use in a number of large scale genome projects. This work is developed in the context of the projects such as ENCODE scale‐up project (National Human Genome Research Institute (NHGRI), two EU IMI project eTOX and Open PAHTS and it will likely be part of the European Infrastructure initiative ELIXIR. Specific examples include genome variation studies and the prediction of the consequences of genetic variation in protein families in the analysis of cancer genome data as part of the ICGC consortium, i.e. the Spanish CLL-ICGC. In the context of the CLL-ICGC project, as well as in the new EU large initiative in epigenomics (Blueprint, partner of the international epigenomic consortium iHEC) the group is responsible of the creation of the federated database infrastructure and annotation strategies that core activities in both projects. In both cases the work is done in collaboration with the CNAG project partner.