Dutch Diagnostic Variant Database (DVD)

About the resource

Type of resource: Variant database
License/availability: Controlled-access data; free to use
Website: Click here to view website
User documentation:
Relevant publication:

Description

Coordinated by the NBIC Bio-Assist program, several groups from Dutch University Medical Centers (LUMC, UMCU, UMCN, UMCG) launched a nation-wide human genomic variant database, the Diagnostic Variant Database (DVD). The purpose is to share all genetic variants detected in the course of next-generation sequencing (NGS) applications between collaborators. This will help medical researchers to distinguish between functionally relevant and benign genetic variants. Therefore, researchers or clinicians can quickly narrow down to those variants that are the potential genetic cause of a particular disease. DVD also allows users to contact the researcher who originally identified a particular genetic mutation. This makes DVD a platform where new research collaboration can be established.

The architecture of the Dutch Variant Database allows sharing of genetic variants detected in the course of next-generation sequencing (NGS) applications without patient information. Only contact details of the submitter are available for every submitted variant. In addition, coverage information is stored to allow assessment of true negatives. This database helps medical researchers to distinguish between functionally relevant and benign genetic variants. DVD allows users to contact the researcher who originally identified a particular genetic mutation. The source code of the DVD system is distributed under the AGPL license. DVD is made available as SOAP webservice. VCF and wiggle coverage files are required for submission.